Jeffrey Zhou is involved with simulation studies of biological systems. He earned a combined B.S./M.S. in molecular biophysics and biochemistry and a B.S. in computer science from Yale University. As a neuroscience research assistant in Junjie Guo’s lab, Jeffrey worked on applying computational and biological tools to study mRNA dysregulation in amyotrophic lateral sclerosis (ALS). Jeffrey adapted unsupervised learning techniques based in graph signal processing to analyze single-cell RNA-seq data using Python, developed a statistical pipeline using R to investigate changes in the mRNA expression of nonsense-mediated decay (NMD) target genes across ALS subtypes, and utilized cell culture techniques to confirm the presence of NMD deficits in a variety of genotypes. In his free time, he enjoys cooking, baking, and playing video games.