Current Opportunities

ASIC Architect and Hardware Engineer
  • Successful candidates will have excellent analytical and communication skills and expertise in the architecture, analysis, or implementation of hardware solutions. Particularly relevant experience would include high-speed (multi-GHz) ASIC design, current custom chip technologies, parallel computation, microprocessor architecture, machine learning acceleration, hardware/software co-design, computer arithmetic, high-speed interconnection networks, and digital systems simulation.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Computational Chemistry/Physics Methods Developer
  • Candidates should have a demonstrated track record of achievement in computational and theoretical chemical physics, applied mathematics, or other computational sciences with a strong background in theory. Relevant areas of experience might include the development of methods for molecular dynamics simulations, such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or statistical approaches for analyzing large data sets. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Drug Discovery Software Associate and Engineer
  • Successful candidates will be creative and independent problem solvers who have excellent communication skills and are extremely detail-oriented. Ideal candidates will have a background or deep interest in scientific research and experience using Python to script and automate scientific workflows, software used for computational drug discovery, and managing chemical data. They should be committed to providing superb support to users of drug discovery and biomolecular simulation software, and have a demonstrated track record of improving past work environments. This position requires familiarity with Linux/UNIX operating systems and Python or other Shell scripting.

    The expected annual base salary for this position is $200,000–$300,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Force Field Developer
  • Candidates should have a demonstrated track record of achievement in force field development or related areas. Relevant areas of experience might include development of physics-based force fields, modeling of polarization and quantum effects, novel parameterization strategies (for example, machine learning, statistical inference, or multi-objective methods), ligand and small molecule parameterization, and force field validation and verification. Specific knowledge of any particular area is less critical, however, than strong research skills, and a record of innovation and accomplishment. Successful candidates will contribute to the development of more accurate force fields for biomolecular simulation.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Information Security Engineer
  • Ideal candidates will have strong knowledge of information security fundamentals, including threat detection and response, vulnerability management, penetration tests, common attack vectors, and endpoint detection and response. Relevant areas of expertise might include operational experience in DevSecOps, developing information security policies and procedures, deploying security tools, and automating the process of detecting and mitigating potential vulnerabilities, in addition to strong programming and scripting ability. Candidates should have excellent communication skills, and we will consider candidates at all levels of experience.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office three days per week, and have the option of working from home the other two days per week.

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Machine Learning Researcher and Engineer
  • Successful hires will expand the group's ongoing efforts applying machine learning to drug discovery, biomolecular simulation, and biophysics. Ideal candidates will have demonstrated expertise in developing deep learning techniques, as well as strong Python programming skills. Relevant areas of experience might include molecular dynamics, structural biology, medicinal chemistry, cheminformatics, and/or quantum chemistry, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement and innovation in the field of machine learning.

    The expected annual base salary for this position is $300,000–$600,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Scientific Associate
  • D. E. Shaw Research is seeking early-career scientists with impressive records of achievement to join the group on a full-time basis. Serious consideration will be given to candidates with strong quantitative abilities, excellent communication skills, and a bachelor's or master's degree in the natural sciences and/or engineering. Successful candidates will work closely with a number of the world's leading biochemists, electrical engineers, and computer scientists, and will have the opportunity to make groundbreaking contributions within the fields of biology, chemistry, and medicine. Scientific Associates are expected to commit to D. E. Shaw Research for a minimum of two years; following their time at D. E. Shaw Research, previous Scientific Associates have gone on to top Ph.D. programs in the country and abroad.

    The expected annual base salary for this position is $200,000–$240,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Scientific Software Developer
  • Successful hires will contribute to software development and workflow engineering for drug discovery, including development of cheminformatics tools and algorithms; large-scale virtual screening and docking; computer-aided molecule design; development of scalable chemical databases; modeling, analysis and visualization of molecular systems; and a range of similar tasks integral to advancing our scientific and drug discovery programs.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Software Developer for Drug Discovery
  • Successful hires will work on developing large-scale scientific workflows to support our drug discovery research efforts. Relevant areas of expertise might include large-scale data analysis, tool integration, workflow engineering/development, high performance data-parallel computing, systems software, machine learning, and Python programming, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Software Engineer, Data Infrastructure
  • Successful hires will directly contribute to creating systems and infrastructure for modeling, curating, and indexing the petabytes of data generated by our special-purpose supercomputers and our large Linux HPC and GPU clusters; to implementing pipelines for processing computational and experimental data sets; and to developing and maintaining data management policies and toolkits for drug discovery data processing.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Systems Software Developer
  • Ideal candidates will have a computer science or engineering degree, prior experience with non-trivial parallel or distributed systems software projects, deep knowledge of operating systems internals, strong debug skills, strong C/C++/Python programming ability, and excellent verbal and written skills. Familiarity with device drivers, Linux or BSD kernels, distributed filesystems, run-time systems, communication protocols, event-driven and thread-based concurrency, bootstrap code, x86 hardware and BIOS, and/or bringup of new hardware is a plus, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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