Current Opportunities

AI In-House Counsel
  • Successful candidates will advise on and help shape the group's ongoing efforts applying machine learning to drug discovery, biomolecular simulation, and biophysics. Responsibilities will include:

    • Identifying and mitigating risks, defining policies, and establishing and maintaining best practices for our artificial intelligence and machine learning work, including in the intellectual property, regulatory, data usage and privacy, cybersecurity, and compliance spaces
    • Negotiating, drafting, and reviewing a broad range of contracts, including agreements relating to our artificial intelligence and machine learning initiatives
    • Advising on the structure of transactions related to our artificial intelligence and machine learning efforts
    • Counseling company leadership on legal and business issues as they arise

    Candidates should have meticulous attention to detail, as well as exceptional writing, communication, analytical, and project management skills. Expertise in the rapidly evolving legal landscape impacting artificial intelligence and machine learning is required, and in-house experience at a technology company is strongly preferred.

    The expected annual base salary for this position is $350,000–$600,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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ASIC Architect and Hardware Engineer
  • Successful candidates will have excellent analytical and communication skills and expertise in the architecture, analysis, or implementation of hardware solutions. Particularly relevant experience would include high-speed (multi-GHz) ASIC design, current custom chip technologies, parallel computation, microprocessor architecture, machine learning acceleration, hardware/software co-design, computer arithmetic, high-speed interconnection networks, and digital systems simulation.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Computational Chemistry/Physics Methods Developer
  • Candidates should have a demonstrated track record of achievement in computational and theoretical chemical physics, applied mathematics, or other computational sciences with a strong background in theory. Relevant areas of experience might include the development of methods for molecular dynamics simulations, such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or statistical approaches for analyzing large data sets. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Force Field Developer
  • Candidates should have a demonstrated track record of achievement in force field development or related areas. Relevant areas of experience might include development of physics-based force fields, modeling of polarization and quantum effects, novel parameterization strategies (for example, machine learning, statistical inference, or multi-objective methods), ligand and small molecule parameterization, and force field validation and verification. Specific knowledge of any particular area is less critical, however, than strong research skills, and a record of innovation and accomplishment. Successful candidates will contribute to the development of more accurate force fields for biomolecular simulation.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Information Security Engineer
  • Ideal candidates will have strong knowledge of information security fundamentals, including threat detection and response, vulnerability management, penetration tests, common attack vectors, and endpoint detection and response. Relevant areas of expertise might include operational experience in DevSecOps, developing information security policies and procedures, deploying security tools, and automating the process of detecting and mitigating potential vulnerabilities, in addition to strong programming and scripting ability. Candidates should have excellent communication skills, and we will consider candidates at all levels of experience.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office three days per week, and have the option of working from home the other two days per week.

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Machine Learning Researcher and Engineer
  • Successful hires will expand the group's ongoing efforts applying machine learning to drug discovery, biomolecular simulation, and biophysics. Ideal candidates will have demonstrated expertise in developing deep learning techniques, as well as strong Python programming skills. Relevant areas of experience might include molecular dynamics, structural biology, medicinal chemistry, cheminformatics, and/or quantum chemistry, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement and innovation in the field of machine learning.

    The expected annual base salary for this position is $300,000–$600,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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ML DevOps Engineer
  • Successful hires will contribute to the management of machine learning (ML) data and development of related infrastructure. Responsibilities could include, for example, optimizing ML models and data; developing/troubleshooting pipelines for ML model training/deployment; and installing/upgrading ML software/libraries. Ideal candidates will have strong practical knowledge of Linux systems, including experience working with GPU clusters and fluent knowledge of Linux/UNIX tools; experience with ML/AI frameworks such as PyTorch and related libraries; familiarity with large-installation systems administration, high performance data-parallel computing, and data management; and strong Python programming ability. Knowledge of C++ would be preferred but is not required. Candidates should also have excellent communication skills.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Scientific Associate
  • Candidates should have experience in computational and theoretical chemical physics, applied mathematics, force field development, or related computational sciences with a strong background in theory. Successful candidates will work on developing physics-based force fields and novel parameterization strategies, methods for molecular dynamics simulations, enhanced sampling, or free energy calculations. Candidates should be completing or have recently completed their bachelor's or master's degree. Scientific Associates are expected to commit for a minimum of two years; following their time at D. E. Shaw Research, previous Scientific Associates have gone on to top Ph.D. programs or joined biotech and pharma companies in the country and abroad.

    The expected annual base salary for this position is $200,000–$240,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Scientific Software Developer
  • Successful hires will contribute to software development and workflow engineering for drug discovery, including development of cheminformatics tools and algorithms; large-scale virtual screening and docking; computer-aided molecule design; development of scalable chemical databases; modeling, analysis and visualization of molecular systems; and a range of similar tasks integral to advancing our scientific and drug discovery programs.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Software Developer Associate
  • Successful candidates will be creative and independent problem solvers who have excellent communication skills and are extremely detail-oriented. Ideal candidates will have experience using Python to script and automate scientific workflows, supporting software used for computational drug discovery, and managing chemical data. They should have strong interest and a demonstrated track record in improving computing environments for end-users. Relevant areas of expertise include familiarity with Linux/UNIX tools, and C++, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $200,000–$300,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Software Developer for Drug Discovery
  • Successful hires will work closely on designing, developing, and supporting software tools, systems, and infrastructure that is critical to our drug discovery and machine learning efforts. Ideal candidates will have strong Python and C++ programming skills, fluency with Linux/UNIX tools, and extensive experience with cheminformatics software packages (for example, virtual screening and docking, computer-aided small molecule design, molecular modeling, and engineering of large-scale chemical databases). Other relevant areas of expertise include workflow engineering and development, software development for cluster architectures, high performance data-parallel computing, and systems software, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Software Developer for ML Data Engineering
  • Successful hires will develop systems and infrastructure for modeling, curating, and indexing petabytes of data (including data generated by our special-purpose supercomputers and Linux clusters); implement pipelines for processing computational and experimental data sets; and develop/optimize workflows to deliver large data sets to machine learning training pipelines. Relevant areas of expertise include engineering of large-scale chemical databases, architecting workflows, and automating processes for the handling of life science data, fluency with Linux/UNIX tools, and familiarity writing scientific software, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Systems Administrator
  • Successful hires will manage systems infrastructure, networks, and information security for our servers and cluster environments, including massively parallel custom supercomputers and Linux clusters ranging from hundreds to thousands of CPU cores and GPUs. Additional responsibilities may include the development and management of large-scale scientific workflows to support our drug discovery research efforts, as well as the management of machine learning data. Ideal candidates will have strong fundamental knowledge of Linux concepts, and relevant areas of expertise might include large-installation systems administration, programming and scripting of distributed systems in Python, high performance data-parallel computing, systems software, and deployment of security tools. Candidates should also have excellent communication skills.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office three days per week, and have the option of working from home the other two days per week.

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Systems Software Developer
  • Ideal candidates will have a computer science or engineering degree, prior experience with non-trivial parallel or distributed systems software projects, deep knowledge of operating systems internals, strong debug skills, strong C/C++/Python programming ability, and excellent verbal and written skills. Familiarity with device drivers, Linux or BSD kernels, distributed filesystems, run-time systems, communication protocols, event-driven and thread-based concurrency, bootstrap code, x86 hardware and BIOS, and/or bringup of new hardware is a plus, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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