Current Opportunities

ASIC Architect and Hardware Engineer
  • Successful candidates will have excellent analytical and communication skills and expertise in the architecture, analysis, or implementation of hardware solutions. Particularly relevant experience would include high-speed (multi-GHz) ASIC design, current custom chip technologies, parallel computation, microprocessor architecture, machine learning acceleration, hardware/software co-design, computer arithmetic, high-speed interconnection networks, and digital systems simulation.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Computational Biophysicist
  • Candidates should have a demonstrated track record of achievement in computational chemistry, biology, or related areas of applied computational research. Relevant areas of experience might include direct application of molecular dynamics or other computational methods to drug discovery, investigation of conformational changes relevant to the function of protein kinases, ion channels, or other biomolecules, structural modeling of protein-protein complexes involved in signal transduction or other cellular processes, or study of fundamental biophysical problems, such as protein and RNA folding. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Computational Chemistry/Physics Methods Developer
  • Candidates should have a demonstrated track record of achievement in computational and theoretical chemical physics, applied mathematics, or other computational sciences with a strong background in theory. Relevant areas of experience might include the development of methods for molecular dynamics simulations, such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or statistical approaches for analyzing large data sets. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Computational Drug Discovery Scientist
  • Ideal candidates will have a demonstrated track record of achievement in computational drug discovery or related areas. Areas of experience relevant to our molecular dynamics-based drug discovery efforts include molecular modeling, fragment-based drug design, cheminformatics, and medicinal chemistry. An ability to leverage experimental data to inform computational approaches would be a plus, as would knowledge of structural biology. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a record of impact in drug discovery. Successful candidates will directly contribute to projects within our expanding portfolio of drug discovery programs, which we pursue both independently and in collaboration with leaders in academia and industry.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Data Engineer
  • Successful hires will directly contribute to creating systems and infrastructure for modeling, curating, and indexing the petabytes of data generated by our special-purpose supercomputers and our large Linux HPC and GPU clusters; to implementing pipelines for processing computational and experimental data sets; and to developing and maintaining data management policies and toolkits for drug discovery data processing.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Drug Discovery Biologist
  • Ideal candidates will have a demonstrated track record of achievement in pre-clinical translational science. This is a high-visibility, high-impact role that affords the opportunity to help shape our drug discovery programs. Relevant areas of experience include leadership of pre-clinical drug discovery programs, design of in vitro assays as well as in vivo disease models, and formulation of translational plans. Specific knowledge of any of these areas is less critical, however, than strong research and communication skills, and a record of impact in drug discovery.

    The expected annual base salary for this position is $350,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Drug Discovery Fellow
  • Candidates should have a Ph.D. and a demonstrated track record of academic or industrial accomplishments. Relevant areas of experience might include direct application of molecular dynamics or machine learning to drug discovery, computer-aided drug design, molecular modeling, cheminformatics, fragment-based approaches, medicinal chemistry, biochemical and biophysical assay development, or target analysis and selection. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment. Successful candidates will directly further the group's drug discovery aims. This is anticipated to be a three-year position.

    The expected annual base salary for this position is $260,000–$290,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Drug Discovery Software Associate and Engineer
  • Successful candidates will be creative and independent problem solvers who have excellent communication skills and are extremely detail-oriented. Ideal candidates will have a background or deep interest in scientific research and experience using Python to script and automate scientific workflows, software used for computational drug discovery, and managing chemical data. They should be committed to providing superb support to users of drug discovery and biomolecular simulation software, and have a demonstrated track record of improving past work environments. This position requires familiarity with Linux/UNIX operating systems and Python or other Shell scripting.

    The expected annual base salary for this position is $200,000–$300,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Force Field Developer
  • Candidates should have a demonstrated track record of achievement in force field development or related areas. Relevant areas of experience might include development of physics-based force fields, modeling of polarization and quantum effects, novel parameterization strategies (for example, machine learning, statistical inference, or multi-objective methods), ligand and small molecule parameterization, and force field validation and verification. Specific knowledge of any particular area is less critical, however, than strong research skills, and a record of innovation and accomplishment. Successful candidates will contribute to the development of more accurate force fields for biomolecular simulation.

    The expected annual base salary for this position is $300,000–$475,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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In-House Counsel
  • Successful candidates will work closely with our team of world-class scientists and engineers, facilitating groundbreaking contributions in science, technology, and drug discovery. Responsibilities will include:

    • Negotiating, drafting, and reviewing contracts in the life sciences and technology spaces, including license agreements, collaboration agreements, master services agreements, and employment and independent contractor agreements
    • Advising on structure of life sciences and technology transactions
    • Helping to establish and maintain internal best practices and policies in areas such as IP, compliance, and information security
    • Advising company leadership on legal and business issues as they arise.

    The expected annual base salary for this position is $350,000–$600,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Machine Learning Researcher and Engineer
  • Successful hires will expand the group's ongoing efforts applying machine learning to drug discovery, biomolecular simulation, and biophysics. Ideal candidates will have demonstrated expertise in developing deep learning techniques, as well as strong Python programming skills. Relevant areas of experience might include molecular dynamics, structural biology, medicinal chemistry, cheminformatics, and/or quantum chemistry, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement and innovation in the field of machine learning.

    The expected annual base salary for this position is $300,000–$600,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Medicinal Chemist
  • Ideal candidates will have considerable experience in structure-based drug discovery projects for multiple target classes. Relevant areas of knowledge include modern synthetic methods and analytical techniques, biochemical/biological assays, basic pharmacology and pharmaceutics, and intellectual property; experience with computational chemistry methods is not required but would be a plus. Specific knowledge of any of these areas is less critical than strong research and communication skills, and a record of impact in drug discovery, such as having advanced multiple compounds to clinical trials.

    The expected annual base salary for this position is $350,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Postdoctoral Fellow
  • Candidates should have expertise in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics. Relevant research areas for postdoctoral fellows span the scientific interests of the group, and include drug discovery, applied computational chemistry and biophysics, methodology development, and force field development.

    The expected annual base salary for this position is $260,000–$290,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Research Scientist and Member of Technical Staff
  • Successful candidates will design and develop algorithms and software for computational chemistry and conduct related scientific research to advance the drug discovery process; discover and develop scientific techniques to direct unprecedented computational power toward the solution of key drug-design problems, including development of novel scientific methodologies for building predictive docking or drug-binding models; develop mathematical methods for molecular dynamics simulations such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or statistical approaches for analyzing large data sets; and analyze biologically important systems using molecular dynamics, free energy perturbation methods, and other statistical mechanical methods.

    Candidates must have a Ph.D. in Mathematics, Physics, Chemistry, or a related quantitative field of study. Knowledge or experience in the following must have been gained through academic research and/or coursework: probability theory; statistical mechanics; stochastic algorithms, including stochastic approximation; scientific computing and numerical methods; programming in Python and C++; and sampling methods, such as molecular dynamics or Markov Chain Monte Carlo.

    The salary range for this position is $300,000–$475,000/year. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Scientific Associate
  • D. E. Shaw Research is seeking early-career scientists with impressive records of achievement to join the group on a full-time basis. Serious consideration will be given to candidates with strong quantitative abilities, excellent communication skills, and a bachelor's or master's degree in the natural sciences and/or engineering. Successful candidates will work closely with a number of the world's leading biochemists, electrical engineers, and computer scientists, and will have the opportunity to make groundbreaking contributions within the fields of biology, chemistry, and medicine. Scientific Associates are expected to commit to D. E. Shaw Research for a minimum of two years; following their time at D. E. Shaw Research, previous Scientific Associates have gone on to top Ph.D. programs in the country and abroad.

    The expected annual base salary for this position is $200,000–$240,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Scientific Software Developer
  • Successful hires will contribute to software development and workflow engineering for drug discovery, including development of cheminformatics tools and algorithms; large-scale virtual screening and docking; computer-aided molecule design; development of scalable chemical databases; modeling, analysis and visualization of molecular systems; and a range of similar tasks integral to advancing our scientific and drug discovery programs.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Software Developer for Drug Discovery
  • Successful hires will work on developing large-scale scientific workflows to support our drug discovery research efforts. Relevant areas of expertise might include large-scale data analysis, tool integration, workflow engineering/development, high performance data-parallel computing, systems software, machine learning, and Python programming, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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Systems Software Developer
  • Ideal candidates will have a computer science or engineering degree, prior experience with non-trivial parallel or distributed systems software projects, deep knowledge of operating systems internals, strong debug skills, strong C/C++/Python programming ability, and excellent verbal and written skills. Familiarity with device drivers, Linux or BSD kernels, distributed filesystems, run-time systems, communication protocols, event-driven and thread-based concurrency, bootstrap code, x86 hardware and BIOS, and/or bringup of new hardware is a plus, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.

    The expected annual base salary for this position is $230,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.

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