Candidates should have world-class credentials in structural or computational biology, and must have unusually strong research skills. Relevant areas of experience might include structural bioinformatics, computational studies of biomolecular interactions, X-ray crystallography, and NMR spectroscopy—but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of interest within the lab include the application of simulation methods to both fundamental and practical problems in molecular biophysics, such as dynamics and allostery. Systems of interest range from ultrafast-folding proteins to functionally significant biomolecules such as protein kinases and membrane transporters.
Candidates should have world-class credentials in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the computation of protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecular systems, free energy perturbation methods, and methods for speeding up evaluation of electrostatic energies—but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of interest within the lab include the prediction of protein structures and binding free energies, structure- and ligand-based drug design, de novo ligand design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations.
Candidates should have world-class credentials in chemistry, physics, or biophysics, or in a relevant area of computational science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the development of physics-based force fields for condensed phase systems, parameterization of existing models for new classes of molecules, the development and application of highly accurate quantum chemical methods for biological and organic molecules, the study of biologically important systems using molecular dynamics and/or Monte Carlo simulation, and the application of statistical mechanics to biomolecular systems—but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement.
D. E. Shaw Research is seeking scientists and engineers with zero to five years of experience who have degrees in chemistry, biology, physics, computer science, engineering, and mathematics from top-tier universities. Serious consideration will be given to candidates with extraordinary records of achievement in the natural sciences and/or computer engineering, exceptional quantitative abilities, and superb communication skills. Successful candidates will work closely with a number of the world’s leading biologists, chemists, electrical engineers, and computer scientists, and will have the opportunity to make groundbreaking contributions within the fields of biology, chemistry, and medicine.